Protamine interacts in the following cases:
Too rapid administration of protamine sulfate may cause severe hypotension and anaphylactoid reactions. Facilities for resuscitation and treatment of shock should be available.
As with most drugs, to be used only if clearly indicated in pregnancy.
As with most drugs, to be used with caution during lactation.
None.
Blood and lymphatic system disorders: anticoagulant effect (when used at doses in excess of that required to neutralise the anticoagulant effect of heparin).
Immune system disorders: hypersensitivity reactions, including angioedema anaphylactoid reactions and fatal anaphylaxis, have been reported.
Cardiac disorders: bradycardia.
Vascular disorders: sudden fall in blood pressure, pulmonary and systemic hypertension, transitory flushing and a feeling of warmth, severe, acute pulmonary vasoconstriction with cardiovascular collapse.
Respiratory, thoracic and mediastinal disorders: Dyspnoea. There have been rare instances of noncardiogenic pulmonary oedema with prolonged hypotension, with significant morbidity and mortality.
Gastrointestinal disorders: nausea and vomiting.
Musculoskeletal and connective tissue disorders: back pain.
General disorders and administration site conditions: lassitude.
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