Chemical formula: C₉H₁₃N₂O₂+ Molecular mass: 181.212 g/mol PubChem compound: 4991
Pyridostigmine is an antagonist to cholinesterase, the enzyme which normally destroys acetylcholine. The action of pyridostigmine can briefly be described, therefore, as the potentiation of naturally occurring acetylcholine. Pyridostigmine has a more prolonged action than neostigmine although it is somewhat slower to take effect (generally taking 30–60 minutes). Because it has a weaker “muscarinic” action than neostigmine, it is usually much better tolerated by myasthenic patients in whom the longer action is also an advantage.
Oral pyridostigmine is poorly absorbed. Maximum plasma concentrations occur at 1 to 2 hours and it is eliminated by the kidney largely unchanged with a half-life of 3 to 4 hours.
There are no preclinical data.
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