Ramucirumab

Therapeutic indications

Ramucirumab is indicated for:

Hepatocellular carcinoma (HCC)

Population group: only adults (18 years old or older)

Ramucirumab monotherapy is indicated for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma who have a serum alpha fetoprotein (AFP) of ≥400 ng/ml and who have been previously treated with sorafenib.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Advanced gastric cancer, gastro-oesophageal junction adenocarcinoma

Population group: only adults (18 years old or older)

Ramucirumab in combination with paclitaxel is indicated for the treatment of adult patients with advanced gastric cancer or gastro-oesophageal junction adenocarcinoma with disease progression after prior platinum and fluoropyrimidine chemotherapy.

Ramucirumab monotherapy is indicated for the treatment of adult patients with advanced gastric cancer or gastro-oesophageal junction adenocarcinoma with disease progression after prior platinum or fluoropyrimidine chemotherapy, for whom treatment in combination with paclitaxel is not appropriate.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Metastatic colorectal cancer (mCRC)

Population group: only adults (18 years old or older)

Ramucirumab, in combination with FOLFIRI (irinotecan, folinic acid, and 5-fluorouracil), is indicated for the treatment of adult patients with metastatic colorectal cancer (mCRC) with disease progression on or after prior therapy with bevacizumab, oxaliplatin and a fluoropyrimidine.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Non-small cell lung cancer

Population group: only adults (18 years old or older)

Ramucirumab in combination with erlotinib is indicated for the first-line treatment of adult patients with metastatic non-small cell lung cancer with activating epidermal growth factor receptor (EGFR) mutations.

Ramucirumab in combination with docetaxel is indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer with disease progression after platinum-based chemotherapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

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