Remifentanil Other names: Remifentanil hydrochloride

Chemical formula: C₂₀H₂₈N₂O₅ Molecular mass: 376.447 g/mol PubChem compound: 60815

Therapeutic indications

Remifentanil is indicated for:

General anaesthesia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

General anesthesia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1 μg/kg by slow bolus injection for ≥30" and thereafter 0.5-1 μg/kg, or 0.5-1 μg/kg/min by continuous infusion and thereafter 0.25-0.4 μg/kg/min based on the concomitant anaesthetic agent

1 μg/kg bolus injection or 0.25 μg/kg/min by continuous infusion and thereafter 0.05-1.3 μg/kg/min based on the concomitant anaesthetic agent

0.5 μg/kg by slow bolus injection for ≥30" or 0.25-0.5 μg/kg/min by continuous infusion and thereafter titration to individual patient need

Cardiac anaesthesia

Population group: only adults (18 years old or older)

Anesthesia for intrathoracic procedure

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1 ug/kg/min by continuous infusion and thereafter 0.003-4.3 ug/kg/min based on the concomitant anaesthetic agent

Contraindications

Remifentanil is contraindicated in the following cases:

Lactation

Effects on ability to drive and use machines

Hypersensitivity to fentanyl analogues

Fentanyl allergy

Irreversible monoamine oxidase inhibitors

Monoamine oxidase inhibitors (MAOIs) and additionally not Reversible inhibitors of monoamine oxidase A (RIMAs)

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