Repotrectinib

Chemical formula: C₁₈H₁₈FN₅O₂ Molecular mass: 355.144 g/mol PubChem compound: 135565923

Therapeutic indications

Repotrectinib is indicated for:

ROS1-positive non-small cell lung cancer

Population group: only adults (18 years old or older)

Repotrectinib as monotherapy is indicated for the treatment of adult patients with ROS1-positive advanced non-small cell lung cancer (NSCLC).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

160 mg once daily for 14 days and thereafter 160 mg twice daily

Advanced solid tumours expressing a NTRK gene fusion

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Repotrectinib as monotherapy is indicated for the treatment of adult and paediatric patients 12 years of age and older with advanced solid tumours expressing a NTRK gene fusion, and

who have received a prior NTRK inhibitor, or
have not received a prior NTRK inhibitor and treatment options not targeting NTRK provide limited clinical benefit, or have been exhausted.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

160 mg once daily for 14 days and thereafter 160 mg twice daily until disease progression or unacceptable toxicity

Contraindications

Repotrectinib is contraindicated in the following cases:

Lactation

Strong or moderate CYP3A or P-gp inhibitors

at least one of

Strong CYP3A4 inhibitors
Cytochrome P-450 CYP3A5 strong inhibitors
Moderate CYP3A4 inhibitors
Cytochrome P-450 CYP3A5 moderate inhibitors

< Previous: Overview

Next: Precautions >

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.