Rivaroxaban

Chemical formula: C₁₉H₁₈ClN₃O₅S  Molecular mass: 435.881 g/mol  PubChem compound: 9875401

Active ingredient description

Rivaroxaban is a highly selective direct factor Xa inhibitor with oral bioavailability. Inhibition of factor Xa interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade, inhibiting both thrombin formation and development of thrombi. Rivaroxaban does not inhibit thrombin (activated factor II) and no effects on platelets have been demonstrated.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
B01AF01 B Blood and blood forming organs → B01 Antithrombotic agents → B01A Antithrombotic agents → B01AF Direct factor Xa inhibitors
Discover more medicines within B01AF01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
XARELTO 15mg/20mg Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC
XARELTO 10mg Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC
XARELTO 15mg Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC
XARELTO 2.5mg Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 366789-02-8
DrugBank Drug: DB06228
KEGG Drug: D07086
PubChem Compound: 9875401
RxNorm Ingredient: 1114195
SNOMED-CT Concept: 442031002
Rivaroxaban (substance)
UNII Identifier: 9NDF7JZ4M3
RIVAROXABAN

Medicines

Rivaroxaban is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Canada (CA)

Cyprus (CY)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Singapore (SG)

Spain (ES)

Tunisia (TN)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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