Rosuvastatin

Chemical formula: C₂₂H₂₈FN₃O₆S Molecular mass: 481.538 g/mol PubChem compound: 446157

Therapeutic indications

Rosuvastatin is indicated for:

Primary hypercholesterolaemia, mixed dyslipidaemia

Population group: only adults (18 - 65 years old)

Adults, adolescents and children aged 6 years or older with primary hypercholesterolaemia (type IIa including heterozygous familial hypercholesterolaemia) or mixed dyslipidaemia (type IIb) as an adjunct to diet when response to diet and other non-pharmacological treatments (e.g. exercise, weight reduction) is inadequate.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5-40 mg once daily

Primary prevention of cardiovascular disease

Population group: only adults (18 - 65 years old)

Prevention of major cardiovascular events in patients who are estimated to have a high risk for a first cardiovascular event, as an adjunct to correction of other risk factors.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

20 mg once daily

Homozygous familial hypercholesterolaemia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Familial hypercholesterolemia - homozygous

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5-20 mg once daily

Heterozygous familial hypercholesterolaemia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Familial hypercholesterolaemia - heterozygous

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5-20 mg once daily

Primary hypercholesterolaemia, mixed dyslipidaemia

Population group: only elderly (65 years old or older)

Adults, adolescents and children aged 6 years or older with primary hypercholesterolaemia (type IIa including heterozygous familial hypercholesterolaemia) or mixed dyslipidaemia (type IIb) as an adjunct to diet when response to diet and other non-pharmacological treatments (e.g. exercise, weight reduction) is inadequate.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5-40 mg once daily

Contraindications

Rosuvastatin is contraindicated in the following cases:

Liver disease

Hepatopathy

Pregnancy

Pregnancy

Lactation

Lactation

Severe renal impairment (creatinine clearance <30 ml/min)

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Myopathy

Disorder of muscle

Ciclosporin

Ciclosporin

Moderate renal impairment (creatinine clearance <60 ml/min)

at least one of

Hypothyroidism

Hypothyroidism

Fibrates

Fibrates

Alcohol abuse

Alcohol abuse

Personal or family history of hereditary muscular disorders

Hereditary progressive muscular dystrophy

< Previous: Overview

Next: Precautions >

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.

⇈