Chemical formula: C₁₉H₁₆N₂O₅ Molecular mass: 352.346 g/mol PubChem compound: 11256664
Roxadustat is a hypoxia-inducible factor, prolyl hydroxylase inhibitor (HIF-PHI). The activity of HIF-PH enzymes controls intracellular levels of HIF, a transcription factor that regulates the expression of genes involved in erythropoiesis. Activation of the HIF pathway is important in the adaptative response to hypoxia to increase red blood cell production.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| B03XA05 | B Blood and blood forming organs → B03 Antianemic preparations → B03X Other antianemic preparations → B03XA Other antianemic preparations | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| EVRENZO Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Roxadustat is an active ingredient of these brands:
Croatia (HR)Estonia (EE)Finland (FI)France (FR)Ireland (IE)Italy (IT)Japan (JP)Lithuania (LT)Poland (PL)Romania (RO)South Africa (ZA)Spain (ES)Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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