Ruxolitinib

Chemical formula: C₁₇H₁₈N₆  Molecular mass: 306.365 g/mol  PubChem compound: 25126798

Therapeutic indications

Ruxolitinib is indicated for:

Myelofibrosis (MF)

Population group: only adults (18 years old or older)

Ruxolitinib is indicated for the treatment of disease-related splenomegaly or symptoms in adult patients with primary myelofibrosis (also known as chronic idiopathic myelofibrosis), post polycythaemia vera myelofibrosis or post essential thrombocythaemia myelofibrosis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Polycythaemia vera (PV)

Population group: only adults (18 years old or older)

Ruxolitinib is indicated for the treatment of adult patients with polycythaemia vera who are resistant to or intolerant of hydroxyurea.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Graft versus host disease

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Ruxolitinib is indicated for the treatment of patients aged 12 years and older with acute graft versus host disease or chronic graft versus host disease who have inadequate response to corticosteroids or other systemic therapies.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Ruxolitinib is contraindicated in the following cases:

Lactation

Lactation

Pregnancy

Pregnancy

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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