Secukinumab

Chemical formula: C₆₅₈₄H₁₀₁₃₄N₁₇₅₄O₂₀₄₂S₄₄ 

Therapeutic indications

Secukinumab is indicated for:

Adult plaque psoriasis

Population group: only adults (18 years old or older)

Secukinumab is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Psoriatic arthritis

Population group: only adults (18 years old or older)

Secukinumab, alone or in combination with methotrexate (MTX), is indicated for the treatment of active psoriatic arthritis in adult patients when the response to previous disease-modifying anti-rheumatic drug (DMARD) therapy has been inadequate.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Paediatric plaque psoriasis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Secukinumab is indicated for the treatment of moderate to severe plaque psoriasis in children and adolescents from the age of 6 years who are candidates for systemic therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Hidradenitis suppurativa

Population group: only adults (18 years old or older)

Secukinumab is indicated for the treatment of active moderate to severe hidradenitis suppurativa (acne inversa) in adults with an inadequate response to conventional systemic HS therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Ankylosing spondylitis (AS, radiographic axial spondyloarthritis)

Population group: only adults (18 years old or older)

Secukinumab is indicated for the treatment of active ankylosing spondylitis in adults who have responded inadequately to conventional therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Non-radiographic axial spondyloarthritis (nr-axSpA)

Population group: only adults (18 years old or older)

Secukinumab is indicated for the treatment of active non-radiographic axial spondyloarthritis with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or magnetic resonance imaging (MRI) evidence in adults who have responded inadequately to non-steroidal anti-inflammatory drugs (NSAIDs).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Juvenile idiopathic arthritis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Enthesitis-related arthritis (ERA)

Secukinumab, alone or in combination with methotrexate (MTX), is indicated for the treatment of active enthesitis-related arthritis in patients 6 years and older whose disease has responded inadequately to, or who cannot tolerate, conventional therapy.

Juvenile psoriatic arthritis (JPsA)

Secukinumab, alone or in combination with methotrexate (MTX), is indicated for the treatment of active juvenile psoriatic arthritis in patients 6 years and older whose disease has responded inadequately to, or who cannot tolerate, conventional therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Secukinumab is contraindicated in the following cases:

Lactation

Lactation

Clinically important active infection, history of recurrent infection

Infectious disease

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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