Selegiline

Chemical formula: C₁₃H₁₇N  Molecular mass: 187.286 g/mol  PubChem compound: 26757

Therapeutic indications

Selegiline is indicated for:

Parkinson's disease

Population group: only adults (18 years old or older)

Selegiline is indicated for the treatment of Parkinson’s disease, or symptomatic parkinsonism. It is used as an adjunct to levodopa (with or without decarboxylase inhibitor). Selegiline in combination with maximal levodopa therapy is indicated particularly in patients who experience fluctuations in their condition such as ‘end-dose’ type fluctuations, ‘on-off’ symptoms or other dyskinesias.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Parkinson's disease

Population group: only adults (18 years old or older)

Selegiline is indicated for the treatment of Parkinson’s disease, or symptomatic parkinsonism. It may be used alone in early Parkinson’s disease for symptomatic relief to delay the need for levodopa (with or without decarboxylase inhibitor).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Selegiline is contraindicated in the following cases:

Selective serotonin reuptake inhibitors (SSRI)

Serotonin noradrenaline reuptake inhibitors (SNRI), tricyclic antidepressants

at least one of
Serotonin–norepinephrine reuptake inhibitors (SNRIs)

Sympathomimetics

Sympathomimetics

MAO inhibitors

Monoamine oxidase inhibitors (MAOIs)

Opioids

Opioids

Triptans

Selective serotonin (5HT1) agonists

Duodenal ulcer, gastric ulcer

at least one of
Duodenal ulcer disease
Gastric ulcer

Lactation

Lactation

Pregnancy

Pregnancy

Effects on ability to drive and use machines

Effects on ability to drive and use machines

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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