Chemical formula: C₁₈₇H₂₉₁N₄₅O₅₉ Molecular mass: 4,113.641 g/mol
Semaglutide is indicated for:
Population group: only adults (18 years old or older)
Semaglutide is indicated for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise as monotherapy when metformin is considered inappropriate due to intolerance or contraindications.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Population group: only adults (18 years old or older)
Semaglutide is indicated as an adjunct to a reduced-calorie diet and increased physical activity for weight management, including weight loss and weight maintenance, in adults with an initial Body Mass Index (BMI) of
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Population group: only adolescents (12 years - 18 years old)
Semaglutide is indicated as an adjunct to a reduced-calorie diet and increased physical activity for weight management in adolescents ages 12 years and above with
Treatment with semaglutide should be discontinued and re-evaluated if adolescent patients have not reduced their BMI by at least 5% after 12 weeks on the 2.4 mg or maximum tolerated dose.
* Obesity (BMI ≥95th percentile) as defined on sex- and age-specific BMI growth charts (CDC.gov) (see Table 1).
Table 1. BMI cut-off points for obesity (≥95th percentile) by sex and age for paediatric patients aged 12 and older (CDC criteria):
| Age (years) | BMI (kg/m²) at 95th Percentile | |
|---|---|---|
| Males | Females | |
| 12 | 24.2 | 25.2 |
| 12.5 | 24.7 | 25.7 |
| 13 | 25.1 | 26.3 |
| 13.5 | 25.6 | 26.8 |
| 14 | 26.0 | 27.2 |
| 14.5 | 26.4 | 27.7 |
| 15 | 26.8 | 28.1 |
| 15.5 | 27.2 | 28.5 |
| 16 | 27.5 | 28.9 |
| 16.5 | 27.9 | 29.3 |
| 17 | 28.2 | 29.6 |
| 17.5 | 28.6 | 30.0 |
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Population group: only adults (18 years old or older)
Semaglutide is indicated for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise in addition to other medicinal products for the treatment of diabetes.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Semaglutide is contraindicated in the following cases:
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