Setmelanotide

Chemical formula: C₄₉H₆₈N₁₈O₉S₂  Molecular mass: 1,117.32 g/mol  PubChem compound: 11993702

Therapeutic indications

Setmelanotide is indicated for:

Obesity associated with loss-of-function biallelic pro-opiomelanocortin

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Setmelanotide is indicated for the treatment of obesity and the control of hunger associated with loss-of-function biallelic pro-opiomelanocortin (POMC), including PCSK1, in adults and children 6 years of age and above.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Obesity associated with leptin receptor deficiency

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Setmelanotide is indicated for the treatment of obesity and the control of hunger associated with deficiency or biallelic leptin receptor (LEPR) deficiency in adults and children 6 years of age and above.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Obesity associated with genetically confirmed Bardet-Biedl syndrome

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Setmelanotide is indicated for the treatment of obesity and the control of hunger associated with genetically confirmed Bardet-Biedl syndrome (BBS) in adults and children 6 years of age and above.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Setmelanotide is contraindicated in the following cases:

Lactation

Lactation

Hepatic impairment

Hepatic insufficiency

End-stage renal disease

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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