Simethicone

Chemical formula: C₆H₁₈O₄Si₃  Molecular mass: 238.461 g/mol  PubChem compound: 6433516

Pharmacodynamic properties

Physiologically the active ingredient is a chemically inert, non-systemic gastric defoaming agent that works by altering the elasticity of interfaces of mucus-embedded bubbles in the gastrointestinal tract.

The gas bubbles are thus broken down or coalesced and in this form gas is more easily eliminated through eructation or passing flatus.

Pharmacokinetic properties

Simeticone is not absorbed from the gastrointestinal tract.

Preclinical safety data

None.

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