Chemical formula: C₂₅H₃₈O₅ Molecular mass: 418.566 g/mol PubChem compound: 54454
Simvastatin has a potent activity in inhibiting HMG-CoA reductase (3-hydroxy–3-ethylglutaryl-CoA-reductase). Simvastatin has been shown to reduce both normal and elevated LDL-C concentrations.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C10AA01 | Simvastatin | C Cardiovascular system → C10 Lipid modifying agents → C10A Lipid modifying agents, plain → C10AA HMG CoA reductase inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| SIMVASTATIN Film-coated tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| ZOCOR Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Simvastatin is an active ingredient of these brands:
Australia (AU)Austria (AT)Brazil (BR)
Canada (CA)Ecuador (EC)Germany (DE)
Hong Kong (HK)Italy (IT)Japan (JP)Poland (PL)Singapore (SG)South Africa (ZA)Spain (ES)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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