Siponimod

Chemical formula: C₂₉H₃₅F₃N₂O₃  Molecular mass: 516.605 g/mol  PubChem compound: 44599207

Therapeutic indications

Siponimod is indicated for:

Secondary progressive multiple sclerosis (SPMS)

Siponimod is indicated for the treatment of adult patients with secondary progressive multiple sclerosis (SPMS) with active disease evidenced by relapses or imaging features of inflammatory activity.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Siponimod is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Immunodeficiency syndrome

AIDS

Progressive multifocal leukoencephalopathy, cryptococcal meningitis

at least one of
Progressive multifocal leukoencephalopathy
Cryptococcal meningitis

Malignancies

Malignant tumour

Severe liver impairment (Child-Pugh class C)

Hepatic failure stage IV

Myocardial infarction, unstable angina pectoris, stroke, transient ischaemic attack (TIA), decompensated heart failure

at least one of
Myocardial infarction
Recent myocardial infarction
Preinfarction syndrome
CVA - Cerebrovascular accident
Temporary cerebral vascular dysfunction
Decompensated chronic heart failure
Heart failure New York Heart Assosiation Class IΙΙ
Heart failure New York Heart Assosiation Class IV

Second-degree Mobitz type II atrioventricular (AV) block, third-degree AV block, sino-atrial heart block, sick-sinus syndrome

at least one of
Mobitz type II atrioventricular block
Complete atrioventricular block
Sinoatrial block
Sick sinus syndrome

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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