Sitaxentan Other names: Sitaxentan sodium

Chemical formula: C₁₈H₁₅ClN₂O₆S₂  Molecular mass: 454.905 g/mol  PubChem compound: 216235

Therapeutic indications

Sitaxentan is indicated for:

Pulmonary arterial hypertension (PAH) classified as WHO functional class III

Population group: only adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Treatment of patients with pulmonary arterial hypertension (PAH) classified as WHO functional class III, to improve exercise capacity. Efficacy has been shown in primary pulmonary hypertension and in pulmonary hypertension associated with connective tissue disease.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Sitaxentan is contraindicated in the following cases:

Lactation

Lactation

Ciclosporin A

Ciclosporin

Mild to severe hepatic impairment (Child-Pugh Class A-C)

Hepatic insufficiency

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Summary of Product Characteristics (SPC) 2011: THELIN Film-coated tablet
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