Valproic acid Other names: Sodium valproate Valproate acid Divalproex sodium

Chemical formula: C₈H₁₆O₂  Molecular mass: 144.211 g/mol  PubChem compound: 3121

Therapeutic indications

Valproic acid is indicated for:

Epilepsy

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treatment of generalised, partial or other epilepsy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Epilepsy

Population group: only adults (18 years old or older)

Treatment of generalised, partial or other epilepsy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Valproic acid is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Active liver disease

Hepatopathy

History of severe hepatic dysfunction

H/O: liver disease

Disorder of the urea cycle metabolism

Disorder of the urea cycle metabolism

Porphyria

Porphyria

Mitochondrial disorders caused by mutations in the nuclear gene encoding the mitochondrial enzyme polymerase γ (POLG)

Sensory ataxic neuropathy with dysarthria and ophthalmoparesis syndrome

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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