Stiripentol

Chemical formula: C₁₄H₁₈O₃  Molecular mass: 234.295 g/mol  PubChem compound: 5311454

Active ingredient description

Stiripentol potentiates the efficacy of other anticonvulsants, such as carbamazepine, sodium valproate, phenytoin, phenobarbital and many benzodiazepines, as the result of pharmacokinetic interactions. The second effect of stiripentol is mainly based on metabolic inhibition of several isoenzymes, in particular CYP450 3A4 and 2C19, involved in the hepatic metabolism of other anti-epileptic medicines.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N03AX17 Stiripentol N Nervous system → N03 Antiepileptics → N03A Antiepileptics → N03AX Other antiepileptics
Discover more medicines within N03AX17

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
DIACOMIT Hard capsule European Medicines Agency (EU) MPI, EU: SmPC
DIACOMIT Capsule / Powder for suspension FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 49763-96-4
DrugBank Drug: DB09118
KEGG Drug: D05928
PubChem Compound: 5311454
RxNorm Ingredient: 2054968
SNOMED-CT Concept: 428221002
Stiripentol (substance)
UNII Identifier: R02XOT8V8I
STIRIPENTOL

Medicines

Stiripentol is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Canada (CA)

Croatia (HR)

Estonia (EE)

Finland (FI)

France (FR)

Ireland (IE)

Japan (JP)

Lithuania (LT)

Netherlands (NL)

Poland (PL)

Romania (RO)

South Africa (ZA)

Spain (ES)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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