Sucroferric oxyhydroxide

Molecular mass: 88.851 g/mol

Therapeutic indications

Sucroferric oxyhydroxide is indicated for:

Chronic kidney disease on dialysis

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Sucroferric oxyhydroxide is indicated for the control of serum phosphorus levels in adult chronic kidney disease (CKD) patients on haemodialysis (HD) or peritoneal dialysis (PD).

Sucroferric oxyhydroxide is indicated for the control of serum phosphorus levels in paediatric patients 2 years of age and older with CKD stages 4-5 (defined by a glomerular filtration rate <30 mL/min/1.73 m²) or with CKD on dialysis.

Sucroferric oxyhydroxide should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy vitamin D₃ or one of its analogues, or calcimimetics to control the development of renal bone disease.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

500-1000 mg daily starting dose and subsequent daily increments every 2-4 weeks until acceptable serum phosphorus level is reached

1,500 mg iron per day, divided across the meals of the day, and subsequent daily increments every 2-4 weeks until acceptable serum phosphorus level is reached

Contraindications

Sucroferric oxyhydroxide is contraindicated in the following cases:

Iron accumulation disorder

Iron overload

Fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase insufficiency

at least one of

Hereditary fructosuria
Congenital glucose-galactose malabsorption
Sucrase-isomaltase deficiency
Sucrose intolerance due to sucrase-isomaltase deficiency
Glucose-galactose malabsorption

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