Tacrolimus

Chemical formula: C₄₄H₆₉NO₁₂ Molecular mass: 804.018 g/mol PubChem compound: 445643

Therapeutic indications

Tacrolimus is indicated for:

Prophylaxis of transplant rejection in liver allograft recipients

Population group: only adults (18 years old or older)

Prophylaxis of transplant rejection in liver allograft recipients.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.01-0.05 mg/kg/day as a continuous 24-hour infusion

0.10-0.20 mg/kg/day in 2 divided doses daily

Prophylaxis of transplant rejection in renal allograft recipients

Population group: only adults (18 years old or older)

Renal transplant rejection

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.05-0.10 mg/kg/day as a continuous 24-hour infusion

0.2-0.3 mg/kg/day in 2 divided doses daily

Prophylaxis of transplant rejection in liver allograft recipients

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Prophylaxis of transplant rejection in liver allograft recipients.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.05 mg/kg/day as a continuous 24-hour infusion

0.30 mg/kg/day in 2 divided doses daily

Prophylaxis of transplant rejection in cardiac allograft recipients

Population group: only adults (18 years old or older)

Cardiac transplant rejection

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.01-0.02 mg/kg/day as a continuous 24-hour infusion

0.075 mg/kg/day in 2 divided doses daily

Prophylaxis of transplant rejection in renal allograft recipients

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Renal transplant rejection

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.075-0.100 mg/kg/day as a continuous 24-hour infusion

0.3 mg/kg/day as a continuous 24-hour infusion

Prophylaxis of transplant rejection in cardiac allograft recipients

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Cardiac transplant rejection

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.03-0.05 mg/kg/day as a continuous 24-hour infusion

0.1-0.3 mg/kg/day in 2 divided doses daily

Severe atopic dermatitis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Treatment of moderate to severe atopic dermatitis in adults who are not adequately responsive to or are intolerant of conventional therapies such as topical corticosteroids.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2 spreads in 2 divided doses daily

Severe atopic dermatitis

Population group: only children (1 year - 12 years old)

Treatment of moderate to severe atopic dermatitis in children who failed to respond adequately to conventional therapies such as topical corticosteroids.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2 spreads in 2 divided doses daily

Contraindications

Tacrolimus is contraindicated in the following cases:

Hypersensitivity to tacrolimus or other macrolides

Allergy to macrolide

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