In the concentrations used for diagnostic examinations, technegas is an inert suspension and has no pharmacological effect.
After inhalation, technegas is absorbed on the walls of pulmonary alveoli and remains in the lungs. There is no intra vascular clearance and elimination of radioactivity is by the physical decay of the technetium-99m.
Part of the carbon micro-particles may be retained in the upper and central airways and is greater in patients with airway obstruction. These particles are cleared by ciliary action and, after swallowing, are eliminated through the gastro-intestinal tract without absorption.
Toxicological data on technetium-99m technegas are not available.
A single administration of inhaled radioactivity of 5.5 MBq in a rat was well tolerated with most of the radioactivity inhaled found in the lung.
Studies of oral administration of solution of Technegas in rats showed that the radioactivity remained almost exclusively in the gastro-intestinal tract.
No study of effects on reproductive functions, of a mutagenic and carcinogenic potential has been carried out.
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