Therapeutic indications
Tenecteplase is indicated for:
Acute myocardial infarction (AMI) with persistent ST elevation or recent left Bundle Branch Block
Population group:
only
adults (18 years old or older)
Tenecteplase is indicated in adults for the thrombolytic treatment of suspected myocardial infarction with persistent ST elevation or recent left Bundle Branch Block within 6 hours after the onset of acute myocardial infarction (AMI) symptoms.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Contraindications
Tenecteplase is contraindicated in the following cases:
Central nervous system damage
at least one of
Neoplasm of central nervous system
Aneurysm of head and neck artery
Operative procedure on head
Operative procedure on spinal structures
Dementia
Dementia
Ischaemic stroke, transient ischaemic attack
at least one of
Ischemic stroke
Temporary cerebral vascular dysfunction
History of transient ischemic attack
Haemorrhagic stroke
CVA - Cerebrovascular accident
Neoplasm with increased bleeding risk
Neoplastic disease and additionally High risk of hemorrhage
Arterial aneurysm, arterial malformation, venous malformation
at least one of
Arterial aneurysm
Arterial malformation
Venous malformation
Active peptic ulceration
Peptic ulcer
Severe hepatic dysfunction, cirrhosis, portal hypertension, hepatitis
at least one of
Hepatic failure stage IV
Cirrhosis of liver
Portal hypertension
Inflammatory disorder of liver
Acute pancreatitis
Acute pancreatitis
Acute pericarditis, subacute bacterial endocarditis
at least one of
Acute pericarditis
Subacute bacterial endocarditis
Cardiopulmonary resuscitation
Cardiopulmonary resuscitation
Recent trauma to the head or cranium
Injury of head
Major surgery, biopsy of a parenchymal organ, significant trauma
at least one of
Surgical procedure
Biopsy
Traumatic injury
Severe uncontrolled hypertension
Hypertensive crisis
Haemorrhagic diathesis
Blood coagulation disorder
Oral anticoagulant treatment
Vitamin K antagonists
