Chemical formula: C₉H₁₄N₅O₄P Molecular mass: 519.448 g/mol PubChem compound: 5481350
Tenofovir disoproxil is absorbed and converted to the active substance tenofovir, which is a nucleoside monophosphate analogue. Tenofovir is then converted to the active metabolite, tenofovir diphosphate, an obligate chain terminator, by constitutively expressed cellular enzymes. Tenofovir diphosphate inhibits HIV-1 reverse transcriptase and the HBV polymerase by direct binding competition with the natural deoxyribonucleotide substrate and, after incorporation into DNA, by DNA chain termination.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| J05AF07 | Tenofovir disoproxil | J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| VIREAD Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Tenofovir disoproxil is an active ingredient of these brands:
United States (US)
Albania (AL)Australia (AU)
Austria (AT)
Brazil (BR)Canada (CA)
Croatia (HR)Cyprus (CY)
Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)Hong Kong (HK)
Ireland (IE)Israel (IL)
Italy (IT)Japan (JP)Lithuania (LT)
Mexico (MX)Netherlands (NL)
New Zealand (NZ)
Nigeria (NG)Poland (PL)
Romania (RO)Singapore (SG)South Africa (ZA)
Spain (ES)Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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