Chemical formula: C₂₆H₃₁Cl₂N₅O₃ Molecular mass: 532.462 g/mol PubChem compound: 441383
Terconazole, an azole antifungal agent, inhibits fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylase enzyme. The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell wall and may be responsible for the antifungal activity of terconazole. Terconazole is used for the local treatment of vulvovaginal candidiasis (moniliasis).
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| G01AG02 | Terconazole | G Genito urinary system and sex hormones → G01 Gynecological antiinfectives and antiseptics → G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS → G01AG Triazole derivatives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| TERCONAZOLE Vaginal suppository | FDA, National Drug Code (US) | MPI, US: SPL/Old | |
| TERCONAZOLE Vaginal cream | MPI, US: SPL/Old |
Terconazole is an active ingredient of these brands:
Brazil (BR)Ecuador (EC)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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