Chemical formula: C₁₂H₉F₃N₂O₂ Molecular mass: 270.207 g/mol PubChem compound: 54684141
Teriflunomide is an immunomodulatory agent with anti-inflammatory properties that selectively and reversibly inhibits the mitochondrial enzyme dihydroorotate dehydrogenase (DHO-DH), which functionally connects with the respiratory chain. As a consequence of the inhibition, teriflunomide generally reduces the proliferation of rapidly dividing cells that depend on de novo synthesis of pyrimidine to expand. The exact mechanism by which teriflunomide exerts its therapeutic effect in MS is not fully understood, but this is mediated by a reduced number of lymphocytes.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L04AK02 | L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AK | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| AUBAGIO Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Teriflunomide is an active ingredient of these brands:
United States (US)Australia (AU)Canada (CA)Cyprus (CY)Ecuador (EC)Finland (FI)Hong Kong (HK)Ireland (IE)Israel (IL)Malta (MT)Mexico (MX)Netherlands (NL)New Zealand (NZ)Singapore (SG)Spain (ES)Tunisia (TN)Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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