Chemical formula: C₁₅H₂₄N₂O₂ Molecular mass: 264.369 g/mol PubChem compound: 5411
Tetracaine interacts in the following cases:
Although the systemic availability of tetracaine by percutaneous absorption of tetracaine is low, caution should be exercised in patients with epilepsy.
There is no specific information as to the safety of tetracaine in pregnancy, although tetracaine has been in wide use for many years without apparent illconsequence. The rapid hydrolysis of tetracaine bv plasma pseudocholinesterase means that it is unlikely to present a significant hazard to the fetus when used as indicated.
It is not known whether tetracaine or its metabolites are secreted in breast milk. Therefore the product is not recommended for use on breast feeding mothers.
No adverse effects on the ability to drive or to use hazardous machinery are expected following use of tetracaine Gel.
May cause transient blurring of vision on instillation. Warn patients not to drive or operate hazardous machinery unless vision is clear.
Slight erythema is frequently seen at the site of application and is due to the pharmacological action of Tetracaine in dilating capillary vessels. This may help delineating the anaesthetised area.
Slight oedema or itching are less frequently seen at the site of application.
This may be due to the local release of histamine and 5-HT.
More severe erythema, oedema and/or itching confined to the site of application have rarely been reported.
In very rare instances, blistering of the skin at the site of application may be apparent – in these cases, remove the gel immediately and treat the affected area symptomatically.
Tetracaine may give rise to dermatitis in hypersensitive patients.
On instillation an initial burning sensation may be experienced. This may last for up to 30 seconds.
Corneal disorders such as superficial punctuate keratitis or edema may be observed following short-term application of tetracaine eye drops for topical anaesthesia.
The cornea may be damaged by prolonged application of anaesthetic eye drops.
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