Chemical formula: C₂₇H₃₃NO₁₀S Molecular mass: 563.62 g/mol PubChem compound: 9915886
Thiocolchicoside interacts in the following cases:
In a fertility study performed in rats, no impairment of fertility was seen at doses up to 12 mg/kg, i.e. at dose levels inducing no clinical effect. Thiocolchicoside and its metabolites exert aneugenic activity at different concentration levels, which is a risk factor for impairment of human fertility.
Thiocolchicoside may predispose to seizures, especially in patients with epilepsy or in those who may have seizures.
There are limited data on the use of thiocolchicoside in pregnant women. Therefore, the potential hazards for the embryo and foetus are unknown. Studies in animals have shown teratogenic effects. Thiocolchicoside is contraindicated during pregnancy and in women of childbearing potential not using contraception.
Since it passes into the mother’s milk, the use of thiocolchicoside is contraindicated during breastfeeding.
In a fertility study performed in rats, no impairment of fertility was seen at doses up to 12 mg/kg, i.e. at dose levels inducing no clinical effect. Thiocolchicoside and its metabolites exert aneugenic activity at different concentration levels, which is a risk factor for impairment of human fertility.
No studies were carried out on the ability to drive or use of machinery. So if drowsiness is a common occurrence, this must be taken in account when driving or using machinery.
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