Chemical formula: OāSā-ā Molecular mass: 114.144 g/mol PubChem compound: 24478
Sodium thiosulfate is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be life-threatening. The primary route of endogenous cyanide detoxification is by enzymatic transulfuration to thiocyanate (SCN-), which is relatively nontoxic and readily excreted in the urine.
Sodium thiosulfate is also indicated for the prevention of ototoxicity induced by cisplatin chemotherapy. The mechanism of protection against ototoxicity may include increasing levels of endogenous antioxidants, inhibition of intracellular oxidative stress, and direct interaction between cisplatin and the thiol group in sodium thiosulfate to produce inactive platinum species.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| V03AB06 | Thiosulfate | V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AB Antidotes |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| SODIUM THIOSULFATE Solution for injection | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| SEACALPHYX Solution for injection | Health Products and Food Branch (CA) | MPI, CA: SPM | |
| PEDMARQSI Solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Thiosulfate is an active ingredient of these brands:
Austria (AT)
Canada (CA)
Croatia (HR)
Ireland (IE)
Italy (IT)
Japan (JP)
Lithuania (LT)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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