Chemical formula: C₁₄H₁₂O₃S Molecular mass: 260.308 g/mol PubChem compound: 5468
Tiaprofenic acid interacts in the following cases:
Congenital abnormalities have been reported in association with NSAID administration in man; however, these are low in frequency and do not appear to follow any discernible pattern. Tiaprofenic acid crosses the placental barrier. Although animal studies have not revealed evidence of teratogenicity, safety in human pregnancy and lactation cannot be assumed and, in common with other NSAIDs, tiaprofenic acid should not be used during the first two trimesters of pregnancy or labour unless the potential benefit to the patient outweighs the potential risk to the foetus.
In view of the known effects of NSAIDs on the foetal cardiovascular system (a closure of ductus arteriosus), use in the last trimester of pregnancy is contraindicated. The onset of labour may be delayed and the duration increased with an increased bleeding tendency in both mother and child.
The level of tiaprofenic acid in mother’s milk has been studied and the total daily exposure is very small; approximately 0.2% of the administered dose and is unlikely to be of pharmacological significance. Breast feeding or treatment of the mother should be stopped as necessary.
The use of tiaprofenic acid may impair female fertility and is not recommended in women attempting to conceive. In women who have difficulties conceiving or who are undergoing investigation of infertility, withdrawal of tiaprofenic acid should be considered.
There is a risk of cross-sensitivity among aspirin and NSAIDs, including the group to which tiaprofenic acid belongs. These pseudo-allergic reactions may include rash, urticaria and angioedema or more potentially severe manifestations (e.g. laryngeal oedema, bronchoconstriction and shock). The risk of pseudo-allergic reactions is greater in patients with recurrent rhino-sinusitis, nasal polyposis or chronic urticaria. Asthmatic patients are particularly at risk of dangerous reactions. Therefore, tiaprofenic acid must not be administered to patients with a history of asthma.
As NSAIDs can interfere with platelet function, they should be used with caution in patients with intracranial haemorrhage and bleeding diathesis.
Undesirable effects such as dizziness, drowsiness, fatigue and visual disturbances are possible after taking NSAIDs. If affected, patients should not drive or operate machinery.
The following adverse reactions are classified by system organ class and ranked under heading of frequency using the following convention: very common (≥10%), common (≥1% and <10%); uncommon (≥0.1% and <1%); rare (≥0.01% and <0.1%), very rare (<0.01%), not known (cannot be estimated from the available data).
Very common: abdominal pain upper
Common: nausea, vomiting, dyspepsia, diarrhoea
Not known: melaena, haematemesis, anorexia, indigestion, heartburn, flatulence, constipation, gastritis, ulcerative stomatitis, pancreatitis, colitis and Crohn’s disease.
Peptic ulcers, gastrointestinal haemorrhage and perforation have occasionally been reported, particularly in the elderly, and in exceptional case may have been associated with fatalities.
Not known: Rash, pruritis, urticaria, purpura, alopecia and erythema and dermatitis bullous (Stevens-Johnson Syndrome or toxic epidermal necrolysis), photosensitivity reaction, angioedema
Common: non-specific allergic reactions, bronchospasm, dyspnea
Not known: hypersensitivity reactions have been reported following treatment with NSAIDs, anaphylactic shock, asthma, especially in subjects allergic to aspirin and other NSAIDs
Not known: thrombocytopenia, anaemia due to bleeding may occur.
Not known: Vertigo, tinnitus and drowsiness.
Common: dizziness
Not known: headaches
Not known: bladder pain, dysuria, and pollakiuria, hematuria may occur
After continuous, prolonged treatment with tiaprofenic acid in presence of urinary symptoms, urinary tract inflammation, have been observed.
NSAIDs have been reported to cause nephrotoxicity in various forms. As with other NSAIDs, isolated cases of tubulo-interstitial nephritis, nephrotic syndrome and renal failure have also been reported with tiaprofenic acid.
Not known: sodium and fluid retention
Not known: hepatitis, jaundice
Common: cystitis
Not known: bleeding time prolonged, abnormal liver function test
Other side-effects that have been reported with NSAIDS but not specifically with tiaprofenic acid are:
Nervous system disorders: optic neuritis
Eye disorders: visual disturbances
Musculoskeletal and connective tissue disorders: paraesthesia
Psychiatric disorders: depression, confusion, hallucinations
General disorders and administration site conditions: fatigue, malaise
Blood and lymphatic system disorders: neutropenia, agranulocytosis, aplastic anaemia, haemolytic anaemia
Nervous disorders: reports of aseptic meningitis (especially in patients with existing auto-immune disorders, such as systemic lupus erythematosus, mixed connective tissue disease), with symptoms such as stiff neck, headache, nausea, vomiting, fever or disorientation
Vascular and cardiac disorders: oedema, hypertension, and cardiac failure, have been reported in association with NSAID treatment
Clinical trial and epidemiological data suggest that use of some NSAIDs (particularly at high doses and in long term treatment) may be associated with an increased risk of arterial thrombotic events (for example myocardial infarction or stroke).
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