Chemical formula: C₂₁H₂₈O₂ Molecular mass: 312.453 g/mol PubChem compound: 444008
Tibolone is rapidly metabolised into three compounds, which all contribute to the pharmacodynamic profile of tibolone. Two of the metabolites (3α-OH-tibolone and 3β-OH-tibolone) have oestrogenic-like activities, whereas the third metabolite (4Δ-isomer of tibolone) has progestogenic and androgenic-like activities.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| G03CX01 | Tibolone | G Genito urinary system and sex hormones → G03 Sex hormones and modulators of the genital system → G03C Estrogens → G03CX Other estrogens |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| TIBOLONE Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Tibolone is an active ingredient of these brands:
Canada (CA)Cyprus (CY)France (FR)Ireland (IE)Israel (IL)Lithuania (LT)Malta (MT)Mexico (MX)New Zealand (NZ)Romania (RO)Singapore (SG)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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