Tiratricol
Chemical formula: C₁₄H₉I₃O₄ Molecular mass: 621.932 g/mol PubChem compound: 5803
Active ingredient description
Tiratricol (3,3',5-triiodothyroacetic acid) is a naturally circulating metabolite of active thyroid hormone (T3) with a high degree of structural similarity and follows the same downward degradation pathway (deiodination and conjugation) and elimination via bile and urine. Tiratricol has been demonstrated to be able to enter MCT8 dependent cells without a functioning MCT8 transporter unlike T3 and T4. Tiratricol can thereby replace T3 in MCT8 dependent tissues and restore normal thyroid hormone activity across tissues.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| D11AX08 | Tiratricol | D Dermatologicals → D11 Other dermatological preparations → D11A Other dermatological preparations → D11AX Other dermatologicals |
| H03AA04 | Tiratricol | H Systemic hormonal preparations, excl. Sex hormones and insulins → H03 Thyroid therapy → H03A Thyroid preparations → H03AA Thyroid hormones |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| EMCITATE Dispersible tablet | MPI, EU: SmPC | European Medicines Agency (EU) |
Medicines
Tiratricol is an active ingredient of these brands:
Estonia (EE)France (FR)Hong Kong (HK)Lithuania (LT)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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