Tobramycin
Chemical formula: C₁₈H₃₇N₅O₉ Molecular mass: 467.515 g/mol PubChem compound: 36294
Active ingredient description
Tobramycin is an aminoglycoside antibiotic produced by Streptomyces tenebrarius. It acts primarily by disrupting protein synthesis leading to altered cell membrane permeability, progressive disruption of the cell envelope and eventual cell death. It is bactericidal at concentrations equal to or slightly greater than inhibitory concentrations.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| J01GB01 | Tobramycin | J Antiinfectives for systemic use → J01 Antibacterials for systemic use → J01G Aminoglycoside antibacterials → J01GB Other aminoglycosides |
| S01AA12 | Tobramycin | S Sensory organs → S01 Ophthalmologicals → S01A Antiinfectives → S01AA Antibiotics |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| TOBI Podhaler Inhalation powder, hard capsule | MPI, EU: SmPC | European Medicines Agency (EU) | |
| TOBRAMYCIN Solution for injection | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) |
Medicines
Tobramycin is an active ingredient of these brands:
Albania (AL)
Australia (AU)Austria (AT)Brazil (BR)
Canada (CA)Croatia (HR)Cyprus (CY)Ecuador (EC)
Estonia (EE)Finland (FI)France (FR)Hong Kong (HK)
Ireland (IE)Israel (IL)Italy (IT)Japan (JP)Lithuania (LT)Malta (MT)Mexico (MX)Netherlands (NL)
New Zealand (NZ)Nigeria (NG)Poland (PL)
Romania (RO)Singapore (SG)South Africa (ZA)
Spain (ES)Tunisia (TN)Turkey (TR)
United Kingdom (UK)United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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