Tofisopam

Tofisopam is the drug from the group of benzodiazepine derivatives (atypical benzodiazepine derivative). Tofisopam has an anxiolytic effect, almost not-accompanied by a sedative, muscle relaxant, anticonvulsant action. Tofisopam is a psychovegetative regulator, it eliminates various forms of autonomic disorders. It has a mild stimulating activity.

Due to the lack miorelaxant effect tofisopam can also be used in patients with myopathy and myasthenia. Because of atypical chemical structure, in contrast to the classical benzodiazepine derivatives, in therapeutic doses tofisopam hardly causes the development of physical, psychological dependence and withdrawal. Tofisopam refers to the day anxiolytics.

Tofisopam is rapidly and almost completely absorbed from the gastrointestinal tract. Blood C_max is reached within 2 hours after which the plasma concentration is reduced monoexponential. Tofisopam not accumulates in the body. Its metabolites do not possess pharmacological activity. Extracted mainly in the urine (60-80%) in the form of conjugates with glucuronic acid and to a lesser extent (about 30%) - with the feces. T_1/2 is 6-8 hours.