Tolcapone

Chemical formula: C₁₄H₁₁NO₅  Molecular mass: 273.241 g/mol  PubChem compound: 4659569

Therapeutic indications

Tolcapone is indicated for:

Idiopathic Parkinson's disease

Population group: only adults (18 - 65 years old)

Tolcapone is indicated in combination with levodopa/benserazide or levodopa/carbidopa for use in patients with levodopa-responsive idiopathic Parkinson’s disease and motor fluctuations, who failed to respond to or are intolerant of other catechol-O-methyltransferase COMT inhibitors. Because of the risk of potentially fatal, acute liver injury, tolcapone should not be considered as a firstline adjunct therapy to levodopa/benserazide or levodopa/carbidopa.

Since tolcapone should be used only in combination with levodopa/benserazide and levodopa/carbidopa, the prescribing information for these levodopa preparations is also applicable to their concomitant use with tolcapone.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Tolcapone is contraindicated in the following cases:

Non-selective mono amino oxidase (MAO) inhibitors

Non selective Monoamine Oxidase Inhibitors

Phaeochromocytoma

Phaeochromocytoma

Neuroleptic Malignant Syndrome (NMS)

Neuroleptic malignant syndrome

Non-traumatic rhabdomyolysis

Non-traumatic rhabdomyolysis

Hyperthermia

Has a temperature

Severe dyskinesia

Dyskinesia

Liver disease, increased liver enzymes

at least one of
Hepatopathy
Serum glutamic oxaloacetic transaminase level raised
Alanine aminotransferase above reference range

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