Tovorafenib

PubChem compound: 25161177

Therapeutic indications

Tovorafenib is indicated for:

Pediatric low-grade glioma harboring a BRAF fusion or rearrangement, or BRAF V600 mutation

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Tovorafenib is indicated for the treatment of patients 6 months of age and older with relapsed or refractory pediatric low-grade glioma (LGG) harboring a BRAF fusion or rearrangement, or BRAF V600 mutation.

This indication is approved under accelerated approval based on response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Tovorafenib is contraindicated in the following cases:

Lactation

Lactation

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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