Chemical formula: C₈H₁₅NO₂ Molecular mass: 157.21 g/mol PubChem compound: 5526
Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin. Tranexamic acid is a competitive inhibitor of plasminogen activation, and at much higher concentrations, a noncompetitive inhibitor of plasmin, i.e., actions similar to aminocaproic acid. Tranexamic acid is about 10 times more potent in vitro than aminocaproic acid. Tranexamic acid binds more strongly than aminocaproic acid to both the strong and weak receptor sites of the plasminogen molecule in a ratio corresponding to the difference in potency between the compounds.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| B02AA02 | Tranexamic acid | B Blood and blood forming organs → B02 Antihemorrhagics → B02A Antifibrinolytics → B02AA Amino acids |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| TRANEXAMIC ACID Tranexamic acid containing medicinal products | European Medicines Agency (EU) | MPI, EU: SmPC | |
| CYKLOKAPRON Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Tranexamic acid is an active ingredient of these brands:
United States (US)Australia (AU)Austria (AT)Canada (CA)Croatia (HR)Ecuador (EC)Estonia (EE)Finland (FI)Ireland (IE)Israel (IL)Italy (IT)Malta (MT)Netherlands (NL)New Zealand (NZ)Poland (PL)Singapore (SG)South Africa (ZA)Spain (ES)Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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