Trastuzumab deruxtecan Other names: Fam-trastuzumab deruxtecan Fam-trastuzumab deruxtecan-nxki

Therapeutic indications

Trastuzumab deruxtecan is indicated for:

HER2-positive breast cancer

Population group: only adults (18 years old or older)

Trastuzumab deruxtecan as monotherapy is indicated for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received one or more prior anti-HER2-based regimens.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

HER2-low breast cancer

Population group: only adults (18 years old or older)

Trastuzumab deruxtecan as monotherapy is indicated for the treatment of adult patients with unresectable or metastatic HER2-low breast cancer who have received prior chemotherapy in the metastatic setting or developed disease recurrence during or within 6 months of completing adjuvant chemotherapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Advanced non-small cell lung cancer with an activating HER2 (ERBB2) mutation

Population group: only adults (18 years old or older)

Trastuzumab deruxtecan as monotherapy is indicated for the treatment of adult patients with advanced NSCLC whose tumours have an activating HER2 (ERBB2) mutation and who require systemic therapy following platinum-based chemotherapy with or without immunotherapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Advanced HER2-positive gastric or gastroesophageal junction adenocarcinoma

Population group: only adults (18 years old or older)

Trastuzumab deruxtecan as monotherapy is indicated for the treatment of adult patients with advanced HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Trastuzumab deruxtecan is contraindicated in the following cases:

Lactation

Lactation

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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