Treosulfan

Chemical formula: C₆H₁₄O₈S₂  Molecular mass: 278.29 g/mol  PubChem compound: 9882105

Therapeutic indications

Treosulfan is indicated for:

Allogeneic haematopoietic stem cell transplantation (alloHSCT)

Population group: only adults (18 years old or older)

Treosulfan in combination with fludarabine is indicated as part of conditioning treatment prior to allogeneic haematopoietic stem cell transplantation (alloHSCT) in adult patients with malignant and non-malignant diseases, and in paediatric patients older than one month with malignant diseases.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Allogeneic haematopoietic stem cell transplantation (alloHSCT)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treosulfan in combination with fludarabine is indicated as part of conditioning treatment prior to allogeneic haematopoietic stem cell transplantation (alloHSCT) in adult patients with malignant and non-malignant diseases, and in paediatric patients older than one month with malignant diseases.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Treosulfan is contraindicated in the following cases:

Pregnancy

Pregnancy

Infectious disease

Infectious disease

Live vaccines

Live organism vaccines

Fanconi anaemia

Fanconi pancytopenia syndrome

Severe cardiac impairment

Cardiac failure

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe liver impairment

Hepatic failure stage IV

Severe lung impairment

Respiratory failure

Hypersensitivity to treosulfan

Treosulfan allergy

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