Chemical formula: C₂₁H₂₈N₂O₅ Molecular mass: 388.457 g/mol PubChem compound: 5577
Trimethobenzamide is used for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis. The mechanism of action of trimethobenzamide as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center; direct impulses to the vomiting center apparently are not similarly inhibited.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| R06AA10 | R Respiratory system → R06 Antihistamines for systemic use → R06A Antihistamines for systemic use → R06AA Aminoalkyl ethers | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| TIGAN Capsule | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| TIGAN Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/Old |
Trimethobenzamide is an active ingredient of these brands:
United States (US)
Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.
