Tropicamide

Chemical formula: C₁₇H₂₀N₂O₂  Molecular mass: 284.353 g/mol  PubChem compound: 5593

Pharmacodynamic properties

Tropicamide is an anticholinergic which blocks the responses of the sphincter muscle of the iris and the ciliary muscle to cholinergic stimulation thus dilating the pupil (mydriasis). At higher concentrations (1%), tropicamide also paralyses accommodation. This preparation acts rapidly and has a relatively short duration of action.

Pharmacokinetic properties

Tropicamide administered topically to the human eye does not bind to tissues as firmly as does atropine. The wash out time for half recovery of carbachol responsiveness was shown to be less than 15 minutes for non-pigmented iris and 30 minutes for pigmented iris.

Preclinical safety data

No further data.

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