Tyrothricin is a circular polypeptide with antibiotic and bacteriostatic activity. It is effective against gram-positive bacteria.
Tyrothricin from Bacillus brevis is a complex mixture of several polypeptides and its main action stems from the content of neutral gramicidins (20%), which neutralise the phosphorylation of the respiration chains. It is effective mainly against gram positive bacteria and cocci, against some fungi and some gram-negative bacteria.
When administrated topically, no significant absorption occurs through the injured skin or mucous membranes. In addition, because tyrothritis, as a peptide, is destroyed by stomach fluids, no plasma concentrations with pharmacological activity are expected when properly administered.
No specific information.
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