Valsartan and Sacubitril

Chemical formula: C₄₈H₅₇N₆Na₃O₉ Molecular mass: 930.388 g/mol

Therapeutic indications

Valsartan and Sacubitril is indicated for:

Symptomatic chronic heart failure with reduced ejection

Population group: only adults (18 years old or older)

Chronic systolic heart failure

For this indication, competent medicine agencies globally authorize below treatments (click for details):

49 mg sacubitril and 51 mg valsartan twice daily doubled at 2-4 weeks to the target dose of 97 mg/103 mg twice daily

Chronic heart failure with left ventricular systolic dysfunction

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Sacubitril/valsartan is indicated in children and adolescents aged one year or older for treatment of symptomatic chronic heart failure with left ventricular systolic dysfunction.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

6 mg/6 mg to 97 mg/103 mg sacubitril/valsartan based on the patient weight, twice daily, doubled every 2-4 weeks to the target dose

Contraindications

Valsartan and Sacubitril is contraindicated in the following cases:

Pregnancy

Lactation

End-stage renal disease

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Hereditary or idiopathic angioedema

at least one of

Hereditary angioneurotic edema
Idiopathic angio-oedema

History of angioedema related to previous ACE inhibitor or ARB therapy

Angioedema caused by angiotensin-converting-enzyme inhibitor

ACE inhibitors

ACE inhibitors, plain

ARB inhibitors

at least one of

Angiotensin II antagonists, plain
Angiotensin II antagonists, combinations

Serum potassium level >5.4 mmol/l in adult patients and >5.3 mmol/l in paediatric patients

Raised serum potassium level

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