22-Oxovincaleukoblastine Other names: Leurocristine Vincristine Vincrystine

Chemical formula: C₄₆H₅₆N₄O₁₀  Molecular mass: 824.972 g/mol  PubChem compound: 5978

Therapeutic indications

22-Oxovincaleukoblastine is indicated for:

Acute lymphocytic leukaemia, chronic lymphocytic leukaemia, acute myelogenous leukaemia, chronic myelogenous leukaemia

Population group: only adults (18 years old or older)

Leukaemias, including acute lymphocytic leukaemia, chronic lymphocytic leukaemia, acute myelogenous leukaemia and blastic crisis of chronic myelogenous leukaemia.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Multiple myeloma

Population group: only adults (18 years old or older)

Multiple myeloma (clinical)

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Malignant lymphomas

Population group: only adults (18 years old or older)

Malignant lymphomas, including Hodgkin’s disease and non-Hodgkin’s lymphomas.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Breast carcinoma

Population group: only adults (18 years old or older)

CA - Carcinoma of breast

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Small cell bronchogenic carcinoma

Population group: only adults (18 years old or older)

Small cell carcinoma of lung

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Head and neck carcinoma

Population group: only adults (18 years old or older)

Malignant tumor of head and neck

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Soft tissue sarcoma

Population group: only adults (18 years old or older)

Sarcoma of soft tissue

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Idiopathic thrombocytopenic purpura (ITP)

Population group: only adults (18 years old or older)

Patients with true ITP refractory to splenectomy and short-term treatment with adrenocortical steroids may respond to vincristine but the medicinal product is not recommended as primary treatment of this disorder. Recommended weekly doses of vincristine given for 3 to 4 weeks have produced permanent remissions in some patients. If patients fail to respond after 3 to 6 doses, it is unlikely that there will be any beneficial results with additional doses.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Ewing's sarcoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Ewing's sarcoma of bone

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Embryonal rhabdomyosarcoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Embryonal rhabdomyosarcoma

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Neuroblastoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Neuroblastoma

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Wilms' tumour

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Nephroblastoma

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Retinoblastoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Retinoblastoma

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Medulloblastoma

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Medulloblastoma

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

22-Oxovincaleukoblastine is contraindicated in the following cases:

Hypersensitivity to vincristine sulfate

Vincristine allergy

Charcot-Marie-Tooth syndrome

Hereditary motor and sensory neuropathy

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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