Chemical formula: C₄₅H₅₄F₂N₄O₈ Molecular mass: 816.944 g/mol
Vinflunine binds to tubulin at or near to the vinca binding sites inhibiting its polymerisation into microtubules, which results in treadmilling suppression, disruption of microtubule dynamic, mitotic arrest and apoptosis.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01CA05 | Vinflunine | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01C Plant alkaloids and other natural products → L01CA Vinca alkaloids and analogues |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| JAVLOR Concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Vinflunine is an active ingredient of these brands:
Austria (AT)
Brazil (BR)
Croatia (HR)
Estonia (EE)
Finland (FI)
France (FR)
Ireland (IE)
Italy (IT)
Lithuania (LT)
Poland (PL)
Singapore (SG)
Spain (ES)
Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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