Molecular mass: 1,355.365 g/mol PubChem compound: 70678590
Vitamin B12 interacts in the following cases:
The serum concentration of hydroxocobalamin may be lowered by co-administration of oral contraceptives.
Parenteral chloramphenicol may attenuate the effect of hydroxocobalamin in anaemia.
Hydroxocobalamin injection should not be used for the treatment of megaloblastic anaemia of pregnancy.
Hydroxocobalamin is secreted into breast milk but is unlikely to harm the infant.
No data available.
Not relevant.
The following undesirable effects may occur with the use of hydroxocobalamin in the following frequencies: Very common (>1/10), Common (>1/100, <1/10), Uncommon (>1/1,000, <1/100), Rare (>1/10,000, <1/1,000), Very rare (<1/10,000), (cannot be estimated from the available data) are not known.
There are no modern clinical studies available that can be used to determine the frequency of undesirable effects. Therefore, all the undesirable effects listed are classed as “frequency unknown”.
The following effects have been reported and are listed below by body system:
Not Known: Reactive thrombocytosis can occur during the first weeks of use in megaloblastic anaemia.
Not Known: Hypersensitivity reactions including rash; itching; exanthema. Antibodies to hydroxocobalamin-transcobalamin II complex have developed during hydroxocobalamin therapy. Anaphylaxis
Not Known: Initial hypokalaemia
Not Known: Headache, paraesthesia, tremor.
Not Known: Arrhythmias secondary to hypokalaemia.
Not Known: Nausea, vomiting, diarrhoea.
Not Known: Fever, chills, hot flushes; dizziness; malaise; pain; Injection site reactions including injection site pain, injection site erythema, injection site pruritus, injection site' induration, and injection site swelling.
Not known: Acneiform and bullous eruptions
Not Known: Chromaturia
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