Vitamin E Other names: Tocopherol Vitamin E

Vitamin E may increase the risk of haemorrhage in patients taking anticoagulants. Vitamin E has been reported to increase bleeding tendency in vitamin-K deficient patients or those taking anticoagulant treatments, it is therefore recommended to monitor the prothrombin time and international normalised ratio (INR) to detect any changes in haemostasis. A possible adjustment of the dose of anticoagulants during and after treatment with Vitamin E Suspension 100 mg/ml may be necessar

Vitamin E may increase the risk of thrombosis in patients taking oestrogens. Vitamin E has been reported to increase the risk of thrombosis in patients predisposed to this condition, including patients taking oestrogens. This finding has not been confirmed but should be borne in mind when selecting patients for treatment, in particular women taking oral contraceptives containing oestrogens.

Cholestyramine, paraffin oil and orlistat induce a decrease in absorption of vitamin E.

There is no evidence of the safety of high doses of vitamin E in pregnancy nor is there evidence from animal work that it is free from hazard, therefore do not use in pregnancy especially in the first trimester.

No information is available on excretion in breast milk, therefore it is advisable not to use during lactation.

None known.

Diarrhoea and abdominal pain may occur with doses greater than 1g daily.