Chemical formula: C₁₇H₁₆FN₃O₂S Molecular mass: 345.39 g/mol PubChem compound: 15981397
Vonoprazan suppresses basal and stimulated gastric acid secretion at the secretory surface of the gastric parietal cell through inhibition of the H+, K+-ATPase enzyme system in a potassium competitive manner. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, vonoprazan has been characterized as a type of gastric proton-pump inhibitor, in that it blocks the final step of acid production. Vonoprazan does not require activation by acid. Vonoprazan may selectively concentrate in the parietal cells in both the resting and stimulated states. Vonoprazan binds to the active pumps in a noncovalent and reversible manner.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A02BC08 | A Alimentary tract and metabolism → A02 Drugs for acid related disorders → A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) → A02BC Proton pump inhibitors | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| VOCINTI Film-coated tablet | Health Sciences Authority (SG) | MPI, Generic | |
| VOQUEZNA Tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Vonoprazan is an active ingredient of these brands:
United States (US)
Brazil (BR)
Estonia (EE)
Japan (JP)Singapore (SG)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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