Voriconazole

Chemical formula: C₁₆H₁₄F₃N₅O  Molecular mass: 349.311 g/mol  PubChem compound: 71616

Therapeutic indications

Voriconazole is indicated for:

Invasive Candida infection

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Treatment of fluconazole-resistant serious invasive Candida infections (including C. krusei).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Serious fungal infections caused by Scedosporium spp. and Fusarium spp

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Treatment of serious fungal infections caused by Scedosporium spp. and Fusarium spp.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Invasive aspergillosis

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Treatment of invasive aspergillosis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Candidemia

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Treatment of candidaemia in non-neutropenic patients.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of invasive fungal infections in allogeneic hematopoietic stem cell transplantation (HSCT)

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Prophylaxis of invasive fungal infections in high risk allogeneic hematopoietic stem cell transplant (HSCT) recipients.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Invasive Candida infection

Population group: only children (1 year - 12 years old)

Treatment of fluconazole-resistant serious invasive Candida infections (including C. krusei).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Serious fungal infections caused by Scedosporium spp. and Fusarium spp

Population group: only children (1 year - 12 years old)

Treatment of serious fungal infections caused by Scedosporium spp. and Fusarium spp.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Candidemia

Population group: only children (1 year - 12 years old)

Treatment of candidaemia in non-neutropenic patients.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of invasive fungal infections in allogeneic hematopoietic stem cell transplantation (HSCT)

Population group: only children (1 year - 12 years old)

Prophylaxis of invasive fungal infections in high risk allogeneic hematopoietic stem cell transplant (HSCT) recipients.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Voriconazole is contraindicated in the following cases:

St. John’s Wort

Hypericum perforatum (St John's Wort)

Ergot alkaloids

at least one of
Ergot alkaloids
Ergot alkaloids
Ergot alkaloids

Ritonavir

Ritonavir

Efavirenz

Efavirenz

Rifampicin, carbamazepine, phenobarbital

at least one of
Rifampicin
Carbamazepine
Phenobarbital

CYP3A4 substrates that can lead to QTc prolongation

Drugs prolonging QT interval and additionally CYP3A4 substrates

Sirolimus

Sirolimus

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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