Chemical formula: C₂₁H₂₁ClN₄OS Molecular mass: 412.936 g/mol PubChem compound: 60854
Ziprasidone has been shown to be an antagonist at both serotonin type 2A (5HT2A) and dopamine type 2 (D2) receptors. It is proposed that the therapeutic activity is mediated, in part, through this combination of antagonist activities. Ziprasidone is also a potent antagonist at 5HT2C and 5HT1D receptors, a potent agonist at the 5HT1A receptor and inhibits neuronal reuptake of norepinephrine and serotonin.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N05AE04 | Ziprasidone | N Nervous system → N05 Psycholeptics → N05A Antipsychotics → N05AE Indole derivatives |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| GEODON Powder for solution for injection | Web Search | MPI, EU: SmPC | |
| ZIPRASIDONE MESYLATE Powder for solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR | |
| GEODON Capsule, hard | Health Products Regulatory Authority (IE) | MPI, EU: SmPC |
Ziprasidone is an active ingredient of these brands:
United States (US)
Austria (AT)
Brazil (BR)
Canada (CA)
Croatia (HR)
Cyprus (CY)
Finland (FI)
Hong Kong (HK)Ireland (IE)
Israel (IL)
Lithuania (LT)Mexico (MX)
New Zealand (NZ)
Poland (PL)
Romania (RO)
Spain (ES)
Tunisia (TN)
Turkey (TR)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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